One person has died following a single-vehicle crash in Livingstone last night.

Around 8:10pm, police received a report of a single-vehicle crash on the Stuart Highway, Livingstone, near the intersection of Livingstone Road.

Bystanders located two male occupants nearby who appeared to have been ejected from a blue Toyota Landcruiser after rolling.

A 21-year-old male was located dead on the scene and a 20-year-old male occupant was located with serious leg and head injuries and was conveyed to Royal Darwin Hospital in a serious condition.

The Stuart Highway was closed in both directions at the crash service as a major emergency response attended including Darwin Traffic Officers, Palmerston General Duties, St John Ambulance and the Critical Response Unit.

The road reopened around 5:30am this morning.

The lives lost on Northern Territory roads this year is now 17.