The Northern Territory Police Force is investigating a fatal crash that occurred this afternoon in Knuckey Lagoon.

Around 1:20pm, the Joint Emergency Services Communication Centre received reports of a two-vehicle collision involving a car and a truck on the Stuart Highway at the Angliss Road intersection, travelling inbound.

Emergency services attended and located an adult male unresponsive. CPR was immediately commenced; however, the driver of the car was pronounced deceased at the scene.

The driver of the truck was assessed for non-life-threatening injuries and did not require further treatment. He returned a negative test for alcohol and illicit drugs.

The Major Crash Investigation Unit is currently on scene with members of Darwin Traffic Operations and investigations are ongoing.

The inbound lane of the Stuart Highway remains closed between Tivendale Road and McMillans Road, and diversions are in place. Delays can be expected.

Police urge anyone with dash-cam footage or information about the crash to make contact on 131 444 quoting reference number P25290596. Anonymous reports can be made through Crime Stoppers on 1800 333 000 or via https://crimestoppersnt.com.au/.

The number of lives lost on Territory roads now stands at 35.