The Northern Territory road toll has risen to 13 following a two-vehicle crash overnight.

The two vehicles collided at the intersection of Berrimah Road and Tiger Brennan Drive just before midnight.

Emergency crews rendered medical assistance to the vehicle occupants however two people, aged 7 and 21, were sadly pronounced deceased. Two others were conveyed to Royal Darwin Hospital with serious injuries.

Major Crash Detectives are investigating the cause of the crash.

Anyone who witnessed the incident is urged to contact police on 131444 or Crime Stoppers on 1800 333 000.