A 55-year-old man has died following a crash on the Stuart Highway 25km north of Ti Tree.

Detective Acting Senior Sergeant Brendan Lindner said the incident occurred just before 6:00pm yesterday.

“For reasons yet known a Toyota Prado travelled onto the wrong side of the road colliding with a truck.

“The driver of the Prado died at the scene. He was the sole occupant of the vehicle.

“Investigations into the exact circumstances surrounding the crash will continue with police investigating if fatigue played a factor.”

The Stuart Highway was closed for several hours and reopened just after midnight.

A file will be prepared for the Coroner.